7-amino-1-methyl-4,5-dihydro-3,1-benzoxazepin-2(1H)-one → 2-{5-Chloro-4-[2-fluoro-6-(tetrahydro-furan-3-yloxy)-phenoxy]-pyrimidin-2-ylamino}-5-methyl-8,9-dihydro-5H-7-oxa-5-aza-benzocyclohepten-6-one
반응식
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:22])[c:6]([O:8][c:9]2[c:10]([F:21])[cH:11][cH:12][cH:13][c:14]2[O:15][CH:16]2[CH2:17][O:18][CH2:19][CH2:20]2)[n:7]1.[NH2:23][c:24]1[cH:25][cH:26][c:27]2[c:28]([cH:36]1)[CH2:29][CH2:30][O:31][C:32](=[O:35])[N:33]2[CH3:34]>>[c:2]1([NH:23][c:24]2[cH:25][cH:26][c:27]3[c:28]([cH:36]2)[CH2:29][CH2:30][O:31][C:32](=[O:35])[N:33]3[CH3:34])[n:3][cH:4][c:5]([Cl:22])[c:6]([O:8][c:9]2[c:10]([F:21])[cH:11][cH:12][cH:13][c:14]2[O:15][CH:16]2[CH2:17][O:18][CH2:19][CH2:20]2)[n:7]1참가 물질
3
반응물 2
생성물 1
출처 및 근거
- ORD 기록
- ord-05e119f94c084e4297fce2d1c97ca544
- 출처 데이터셋
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
반응 노트
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