Dichloromethane → 2-{4-[2-cyclopentyl-1-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-ethyl]-benzenesulfonyl}-ethanol

반응식

[B:32]([Br:33])([Br:34])[Br:35].[CH:1]1([CH2:6][CH:7]([c:8]2[cH:9][cH:10][c:11]([S:14](=[O:15])(=[O:16])[CH2:17][CH2:18][O:19][CH2:20][CH3:21])[cH:12][cH:13]2)[c:22]2[cH:23][c:24]3[c:25]([n:26][cH:27][c:28]([F:30])[cH:29]3)[nH:31]2)[CH2:2][CH2:3][CH2:4][CH2:5]1.[Cl:36][CH2:37][Cl:38]>>[CH:1]1([CH2:6][CH:7]([c:8]2[cH:9][cH:10][c:11]([S:14](=[O:15])(=[O:16])[CH2:17][CH2:18][OH:19])[cH:12][cH:13]2)[c:22]2[cH:23][c:24]3[c:25]([n:26][cH:27][c:28]([F:30])[cH:29]3)[nH:31]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 25134Boron tribromide

HCID 672289932-{2-cyclopentyl-1-[4-(2-ethoxy-ethanesulfonyl)-phenyl]-ethyl}-5-fluoro-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 532520282-{4-[2-cyclopentyl-1-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-ethyl]-benzenesulfonyl}-ethanol

출처 및 근거

ORD 기록: ord-f5c893ae56dd49c880f8bcd38f0e183a
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

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