Methyl 3-aminothieno(2,3-b)pyridine-2-carboxylate → Methyl thieno[2,3-b]pyridine-2-carboxylate

HRID 15423

반응식

HRID 15423 반응식
N[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[S:4][C:3]=1[C:11]([O:13][CH3:14])=[O:12].N([O-])=O.[Na+]>>[S:4]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:10]2[CH:2]=[C:3]1[C:11]([O:13][CH3:14])=[O:12]

참가 물질

3

반응물 2

HCID 2820896Methyl 3-aminothieno(2,3-b)pyridine-2-carboxylateHCID 23668193Sodium Nitrite

생성물 1

HCID 19007380Methyl thieno[2,3-b]pyridine-2-carboxylate

실험 절차

The synthesis is carried out according to the general procedure; for work-up, the resulting precipitate is filtered off with suction and washed twice with water and three times with ethyl acetate. The organic phase of the resulting filtrate is separated off, dried and concentrated. Using 0.22 g (1.07 mmol) of methyl 3-aminothieno[2,3-b]pyridine-2-carboxylate and 0.24 g (3.41 mmol) of sodium nitrite, 84 mg (41% of theory) of the desired product are obtained.

후처리

  1. filtrationfor work-up, the resulting precipitate is filtered off with suction
  2. washwashed twice with water and three times with ethyl acetate
  3. customThe organic phase of the resulting filtrate is separated off
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-92077d7b20d8411693216d3d67a73140
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732477B2

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