Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Methyl 6-cyanobenzo[b]thiophene-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl Thioglycolate | HCID 16907 | — |
| 반응물 | 4-Formyl-3-nitrobenzonitrile | HCID 13238550 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Methyl 6-cyanobenzo[b]thiophene-2-carboxylate | HCID 11031280 | — |
반응 단계
4.08 g (23.2 mmol) of 4-cyano-2-nitrobenzaldehyde, 2.46 g (23.2 mmol) of methyl mercaptoacetate and 6.46 ml (46.4 mmol) of triethylamine in 12.3 ml of DMSO are heated at 80° C. for 2.5 h. The reaction solution is poured into 400 ml of ice-water. After addition of 4 ml of acetic acid, the resulting precipitate is filtered off with suction, washed twice with water and dried at 50° C. under reduced pressure overnight. This gives 4.19 g (83.2% of theory) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732477B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-1a82eeaf1a20452689323b89dcd1d2e5 |
| 출처 메모 | uspto-grants-2010_06 |