Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 4-fluoro-N-{4-fluoro-3-nitrophenyl}benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Fluorobenzenesulfonyl chloride | HCID 9588 | — |
| 반응물 | 4-Fluoro-3-nitroaniline | HCID 67768 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-fluoro-N-{4-fluoro-3-nitrophenyl}benzenesulfonamide | HCID 798928 | 80.7% |
반응 단계
Pyridine (500 uL, 6.19 mmol) was added to a solution of 4-fluoro-3-nitro-phenylamine (1 g, 6.41 mmol) and 4-fluoro-benzenesulfonyl chloride (1.2 g, 6.19 mmol) in dichloromethane (DCM) (20 mL) and the reaction was stirred at room temperature overnight. The reaction was then partitioned between water and DCM. The organic layer was washed several times with water and concentrated. Recrystalization from ethanol/water gave 1.57 g of the sub-title compound as tan crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732618B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-6f17df37e00a4352aac9ba84d1fdc378 |
| 출처 메모 | uspto-grants-2010_06 |