Butanal → [5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

HRID 15527

반응식

HRID 15527 반응식
[C:1]([O:5][C:6](=[O:27])[CH2:7][NH:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])=[CH:11][C:10]=1[NH2:26])([CH3:4])([CH3:3])[CH3:2].[CH:28](=O)[CH2:29][CH2:30][CH3:31]>C(O)C.C(O)(=O)C>[C:1]([O:5][C:6](=[O:27])[CH2:7][N:8]1[C:9]2[CH:14]=[CH:13][C:12]([NH:15][S:16]([C:19]3[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=3)(=[O:18])=[O:17])=[CH:11][C:10]=2[N:26]=[C:28]1[CH2:29][CH2:30][CH3:31])([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 2

HCID 261ButanalHCID 67199324[2-Amino-4-(4-fluoro-benzenesulfonylamino)-phenylamino]-acetic acid tert-butyl ester

생성물 1

HCID 67201670[5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

시약·촉매·용매 2

HCID 176Acetic Acid촉매HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

The product from step c.) (100 mg, 0.25 mmol) was dissolved in ethanol (5 mL) and treated with acetic acid (2 drops) followed by butyraldehyde (35 uL, 0.39 mmol). The reaction was heated to 70° C. for 18 hours. The reaction mixture was cooled to ambient temperature and concentrated under reduced pressure to give the crude sub-title compound that was used without further purification.

후처리

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2451222b1e724e918f6a55eac24a9455
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732618B2

연결된 노트

불러오는 중…