Pyridine → 4-fluoro-N-{4-fluoro-3-nitrophenyl}benzenesulfonamide

HRID 15540

반응식

HRID 15540 반응식
N1C=CC=CC=1.[F:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16].[F:18][C:19]1[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1>C(Cl)Cl>[F:18][C:19]1[CH:24]=[CH:23][C:22]([S:25]([NH:14][C:11]2[CH:12]=[CH:13][C:8]([F:7])=[C:9]([N+:15]([O-:17])=[O:16])[CH:10]=2)(=[O:27])=[O:26])=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 95884-Fluorobenzenesulfonyl chlorideHCID 677684-Fluoro-3-nitroaniline

생성물 1

HCID 7989284-fluoro-N-{4-fluoro-3-nitrophenyl}benzenesulfonamide수율 80.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Pyridine (500 μL, 6.19 mmol) was added to a solution of 4-fluoro-3-nitro-phenylamine (1 g, 6.41 mmol) and 4-fluoro-benzenesulfonyl chloride (1.2 g, 6.19 mmol) in DCM (20 mL) and the reaction was stirred at room temperature overnight. The reaction was then partitioned between water and DCM. The organic layer was washed several times with water and concentrated. Recrystalization from ethanol/water gave 1.57 g of the sub-title compound as tan crystals.

후처리

  1. customThe reaction was then partitioned between water and DCM
  2. washThe organic layer was washed several times with water
  3. concentrationconcentrated
  4. customRecrystalization from ethanol/water

출처 및 근거

ORD 기록
ord-aa3756eb13b24f6fa6a98ce382f27114
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732618B2

연결된 노트

불러오는 중…