Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 15541생성일: 2026년 10월 24일
Acetic Acid → [5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester
https://huagongshe.com/ko/reaction/15541
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Butanal | HCID 261 | — |
| 반응물 | [2-Amino-4-(4-fluoro-benzenesulfonylamino)-phenylamino]-acetic acid tert-butyl ester | HCID 67199324 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | [5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester | HCID 67201670 | — |
반응 단계
Butyraldehyde (3.8 mL, 41.8 mmol) and acetic acid (1.4 mL) were added to a solution of [2-amino-4-(4-fluoro-benzenesulfonylamino)-phenylamino]-acetic acid tert-butyl ester (12.5 g, 26.8 mmol) in EtOH (135 mL), and stirred overnight at 70° C. The reaction mixture was cooled to ambient temperature and concentrated under reduced pressure to give the crude sub-titled compound that was used without further purification. MS calculated for C22H26FN3O4S—H: 446, observed: 446.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07732618B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-7210e5014eab4c069930c927dd1fe75b |
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| 출처 메모 | uspto-grants-2010_06 |
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