Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 15546생성일: 2026년 10월 23일
1-Chloro-4-(chloromethyl)benzene → {5-[(4-Chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester
https://huagongshe.com/ko/reaction/15546
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | [5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester | HCID 67201670 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | {5-[(4-Chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester | HCID 67199541 | — |
반응 단계
4-Chlorobenzyl chloride (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07732618B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-f15124e661274eb8982f6080f0da4c3e |
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| 출처 메모 | uspto-grants-2010_06 |
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