N-methyl-2-pyrrolidone → 4-({3-chloro-4-[(1-methyl-1H-imidazole-2-yl)thio]phenyl}amino)-6-methoxy-7-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]quinoline-3-carbonitrile

반응식

[CH3:31][N:32]1[CH2:33][CH2:34][N:35]([CH:38]2[CH2:39][CH2:40][NH:41][CH2:42][CH2:43]2)[CH2:36][CH2:37]1.[CH3:44][N:45]1[CH2:46][CH2:47][CH2:48][C:49]1=[O:50].[Cl:1][c:2]1[cH:3][c:4]([NH:15][c:16]2[c:17]([C:29]#[N:30])[cH:18][n:19][c:20]3[cH:21][c:22]([F:28])[c:23]([O:26][CH3:27])[cH:24][c:25]23)[cH:5][cH:6][c:7]1[S:8][c:9]1[n:10]([CH3:14])[cH:11][cH:12][n:13]1>>[Cl:1][c:2]1[cH:3][c:4]([NH:15][c:16]2[c:17]([C:29]#[N:30])[cH:18][n:19][c:20]3[cH:21][c:22]([N:41]4[CH2:40][CH2:39][CH:38]([N:35]5[CH2:34][CH2:33][N:32]([CH3:31])[CH2:37][CH2:36]5)[CH2:43][CH2:42]4)[c:23]([O:26][CH3:27])[cH:24][c:25]23)[cH:5][cH:6][c:7]1[S:8][c:9]1[n:10]([CH3:14])[cH:11][cH:12][n:13]1