Potassium Carbonate → {5-[(4-Fluoro-benzenesulfonyl)-(3-phenyl-propyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	(3-Bromopropyl)benzene	HCID 12503	—
반응물	[5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester	HCID 67201670	—
용매	Water	HCID 962	—
용매	Acetonitrile	HCID 6342	—
용매	Ethyl Acetate	HCID 8857	—
생성물	{5-[(4-Fluoro-benzenesulfonyl)-(3-phenyl-propyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester	HCID 67201939	—

반응 조건

온도	80 °C

반응 단계

1-Bromo-3-phenylpropane (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07732618B2
출처 데이터셋	uspto-grants-2010_06
ORD ID	ord-3b6613ae05cb402db4752cca7360d5c0
출처 메모	uspto-grants-2010_06