tert-Butyl isothiocyanate → 6-Arylpyrido[2,3-d]pyrimidine deriv. 82

반응식

[C:31]([CH3:32])([CH3:33])([CH3:34])[N:35]=[C:36]=[S:37].[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:8][CH2:9][CH2:10][NH:11][c:12]2[n:13][cH:14][c:15]3[c:16]([n:17]2)[n:18][c:19]([NH2:30])[c:20](-[c:22]2[c:23]([Cl:29])[cH:24][cH:25][cH:26][c:27]2[Cl:28])[cH:21]3)[CH2:6][CH2:7]1>>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:8][CH2:9][CH2:10][NH:11][c:12]2[n:13][cH:14][c:15]3[c:16]([n:17]2)[n:18][c:19]([NH:30][C:36]([NH:35][C:31]([CH3:32])([CH3:33])[CH3:34])=[S:37])[c:20](-[c:22]2[c:23]([Cl:29])[cH:24][cH:25][cH:26][c:27]2[Cl:28])[cH:21]3)[CH2:6][CH2:7]1

참가 물질

반응물 2

HCID 11544tert-Butyl isothiocyanate

HCID 53281486-(2,6-dichlorophenyl)-2-N-[3-(4-methylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine

생성물 1

HCID 53281846-Arylpyrido[2,3-d]pyrimidine deriv. 82

출처 및 근거

ORD 기록: ord-cf6dfa4ca1cc4da99eee349ed6a2c8d1
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

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