Potassium Carbonate → {5-[(4-Trifluoromethoxy-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

HRID 15566

반응식

HRID 15566 반응식
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Br)=[CH:6][CH:5]=1.C([O-])([O-])=O.[K+].[K+].[C:20]([O:24][C:25](=[O:50])[CH2:26][N:27]1[C:31]2[CH:32]=[CH:33][C:34]([NH:36][S:37]([C:40]3[CH:45]=[CH:44][C:43]([F:46])=[CH:42][CH:41]=3)(=[O:39])=[O:38])=[CH:35][C:30]=2[N:29]=[C:28]1[CH2:47][CH2:48][CH3:49])([CH3:23])([CH3:22])[CH3:21]>CC#N.CCOC(C)=O.O>[C:20]([O:24][C:25](=[O:50])[CH2:26][N:27]1[C:31]2[CH:32]=[CH:33][C:34]([N:36]([CH2:8][C:7]3[CH:10]=[CH:11][C:4]([O:3][C:2]([F:13])([F:12])[F:1])=[CH:5][CH:6]=3)[S:37]([C:40]3[CH:41]=[CH:42][C:43]([F:46])=[CH:44][CH:45]=3)(=[O:38])=[O:39])=[CH:35][C:30]=2[N:29]=[C:28]1[CH2:47][CH2:48][CH3:49])([CH3:23])([CH3:22])[CH3:21]

참가 물질

7

반응물 3

HCID 11430Potassium CarbonateHCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 67201670[5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

생성물 1

HCID 67201038{5-[(4-Trifluoromethoxy-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

시약·촉매·용매 3

HCID 962Water용매HCID 6342Acetonitrile용매HCID 8857Ethyl Acetate용매

반응 조건

온도
80 °C

실험 절차

4-Trifluoromethoxybenzyl bromide (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

후처리

  1. filtrationfiltered through an Extrelut column
  2. washThe column was washed with EtOAc
  3. concentrationthe filtrate was concentrated
  4. customThe crude product was carried onto the next reaction without any further purification or characterization

출처 및 근거

ORD 기록
ord-b7350f90ec124e1e899792b5d84ccecf
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732618B2

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