Ammonia → Oseltamivir

HRID 15606

반응식

HRID 15606 반응식
[CH3:1][CH2:2][CH:3]([O:6][C@H:7]1[C@H:12]([NH:13][C:14]([CH3:16])=[O:15])[C@@H:11]([NH2:17])[CH2:10][C:9]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:8]1)[CH2:4][CH3:5].OP(O)(O)=O.O.N>C(Cl)Cl>[CH3:5][CH2:4][CH:3]([O:6][C@H:7]1[C@H:12]([NH:13][C:14]([CH3:16])=[O:15])[C@@H:11]([NH2:17])[CH2:10][C:9]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:8]1)[CH2:2][CH3:1]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 962WaterHCID 78000Tamiflu

생성물 1

HCID 65028Oseltamivir수율 108.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Oseltamivir phosphate (20 gm, HPLC purity: 97%) is stirred with water (100 ml) and methylene chloride (100 ml) for 10 minutes at 25-30° C. and then pH of the mass is adjusted to 9-10 with liquor ammonia. Separated the layers, the organic layer is subjected to carbon treatment and filtered on hiflo bed. Washed the hiflo bed with methylene chloride (20 ml) and then distilled the organic layer under vacuum at 40° C. to give 16.5 gm of oseltamivir free base as a residue.

후처리

  1. customSeparated the layers
  2. filtrationfiltered on hiflo bed
  3. washWashed the hiflo bed with methylene chloride (20 ml)
  4. distillationdistilled the organic layer under vacuum at 40° C.

출처 및 근거

ORD 기록
ord-950cdd41c55d4453b1774526ef2cfe7b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732632B2

연결된 노트

불러오는 중…