참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,3-Dihydroxybutanedioic Acid | HCID 875 | — |
| 반응물 | Oseltamivir | HCID 65028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Oseltamivir tartrate | HCID 16667738 | 97.6% |
반응 단계
Tartaric acid (5 gm) is added to the solution of oseltamivir free base (9 gm, HPLC purity: 95.8%) in ethyl acetate (50 ml) at 25-30° C., the contents are heated to 50° C. and then slowly cooled to 30° C. in 1 hour. Filtered the solid, washed with 70 ml of ethyl acetate and dried to yield 13 gm of oseltamivir tartrate (HPLC purity: 97.2%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07732632B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-db3afd7ac0164b48b415eb3b440f1a36 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
