Dichloromethane → N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((4-aminopiperidin-1-yl)methyl)quinazolin-4-amine

반응식

[Cl:51][CH2:52][Cl:53].[F:1][c:2]1[cH:3][c:4]([CH2:5][n:6]2[n:7][cH:8][c:9]3[cH:10][c:11]([NH:15][c:16]4[n:17][cH:18][n:19][c:20]5[cH:21][cH:22][cH:23][c:24]([CH2:26][N:27]6[CH2:28][CH2:29][CH:30]([NH:33][C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[CH2:31][CH2:32]6)[c:25]45)[cH:12][cH:13][c:14]23)[cH:41][cH:42][cH:43]1.[F:44][C:45]([F:46])([F:47])[C:48]([OH:49])=[O:50]>>[F:1][c:2]1[cH:3][c:4]([CH2:5][n:6]2[n:7][cH:8][c:9]3[cH:10][c:11]([NH:15][c:16]4[n:17][cH:18][n:19][c:20]5[cH:21][cH:22][cH:23][c:24]([CH2:26][N:27]6[CH2:28][CH2:29][CH:30]([NH2:33])[CH2:31][CH2:32]6)[c:25]45)[cH:12][cH:13][c:14]23)[cH:41][cH:42][cH:43]1