Resorcinol → 4-(chloromethyl)-7-hydroxy-2H-chromen-2-one

HRID 15645

반응식

HRID 15645 반응식
[Cl:1][CH2:2][C:3](=O)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[C:11]1([CH:18]=CC=[C:14](O)[CH:13]=1)[OH:12]>S(=O)(=O)(O)O>[Cl:1][CH2:2][C:3]1[C:9]2[C:8](=[CH:18][C:11]([OH:12])=[CH:13][CH:14]=2)[O:7][C:5](=[O:6])[CH:4]=1

참가 물질

4

반응물 2

HCID 5054ResorcinolHCID 69484Ethyl 4-chloroacetoacetate

생성물 1

HCID 53988464-(chloromethyl)-7-hydroxy-2H-chromen-2-one수율 84%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

Under ice-cooling, ethyl 4-chloroacetoacetate (14.0 g, 85.0 mmol) was dissolved in concentrated sulfuric acid (30 mL), resorcinol (8.81 g, 80.0 mmol) was added by small portions, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was poured into ice water, and the precipitated solid was collected by filtration, washed with water, and air-dried to give the title compound (14.1 g, yield 84%) as a beige powder.

후처리

  1. temperatureUnder ice-cooling
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with water
  4. customair-dried

출처 및 근거

ORD 기록
ord-fe0b5de1698444ec8b5a4db7374edae3
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732626B2

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