Resorcinol → 4-(chloromethyl)-7-hydroxy-2H-chromen-2-one
반응식
[Cl:1][CH2:2][C:3](=O)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[C:11]1([CH:18]=CC=[C:14](O)[CH:13]=1)[OH:12]>S(=O)(=O)(O)O>[Cl:1][CH2:2][C:3]1[C:9]2[C:8](=[CH:18][C:11]([OH:12])=[CH:13][CH:14]=2)[O:7][C:5](=[O:6])[CH:4]=1참가 물질
4
실험 절차
Under ice-cooling, ethyl 4-chloroacetoacetate (14.0 g, 85.0 mmol) was dissolved in concentrated sulfuric acid (30 mL), resorcinol (8.81 g, 80.0 mmol) was added by small portions, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was poured into ice water, and the precipitated solid was collected by filtration, washed with water, and air-dried to give the title compound (14.1 g, yield 84%) as a beige powder.
후처리
- temperatureUnder ice-cooling
- filtrationthe precipitated solid was collected by filtration
- washwashed with water
- customair-dried
출처 및 근거
- ORD 기록
- ord-fe0b5de1698444ec8b5a4db7374edae3
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07732626B2
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