1-Benzyl-5-chloro-2-oxo-1,2-dihydro-3-pyridinecarboxylic acid → 1-benzyl-5-chloro-N-(3-fluoro-4-(2-(3-(4-methylpiperazin-1-yl)prop-1-ynyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

반응식

[CH2:29]([c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)[n:36]1[c:37](=[O:46])[c:38]([C:43](=[O:44])[OH:45])[cH:39][c:40]([Cl:42])[cH:41]1.[F:1][c:2]1[cH:3][c:4]([NH2:28])[cH:5][cH:6][c:7]1[O:8][c:9]1[c:10]2[c:11]([n:12][cH:13][cH:14]1)[cH:15][c:16]([C:18]#[C:19][CH2:20][N:21]1[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]1)[s:17]2>>[F:1][c:2]1[cH:3][c:4]([NH:28][C:43]([c:38]2[c:37](=[O:46])[n:36]([CH2:29][c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[cH:41][c:40]([Cl:42])[cH:39]2)=[O:44])[cH:5][cH:6][c:7]1[O:8][c:9]1[c:10]2[c:11]([n:12][cH:13][cH:14]1)[cH:15][c:16]([C:18]#[C:19][CH2:20][N:21]1[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]1)[s:17]2