Dichloromethane → 5-(2,2-Difluoro-1-hydroxyethyl)-2',4'-difluorobiphenyl-3-carboxylic acid

반응식

[Cl:34][CH2:35][Cl:36].[F:1][CH:2]([CH:3]([OH:4])[c:5]1[cH:6][c:7]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[cH:8][c:9](-[c:11]2[c:12]([F:18])[cH:13][c:14]([F:17])[cH:15][cH:16]2)[cH:10]1)[F:26].[OH:27][C:28]([C:29]([F:30])([F:31])[F:32])=[O:33]>>[F:1][CH:2]([CH:3]([OH:4])[c:5]1[cH:6][c:7]([C:19](=[O:20])[OH:21])[cH:8][c:9](-[c:11]2[c:12]([F:18])[cH:13][c:14]([F:17])[cH:15][cH:16]2)[cH:10]1)[F:26]

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 68500331Tert-butyl 5-(2,2-difluoro-1-hydroxyethyl)-2',4'-difluorobiphenyl-3-carboxylate

생성물 1

HCID 684984575-(2,2-Difluoro-1-hydroxyethyl)-2',4'-difluorobiphenyl-3-carboxylic acid

출처 및 근거

ORD 기록: ord-7d252442e1cc43459d615d1eb7fd8242
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

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