Methane → 4,5-Dihydrotetrazolo[1,5-a]quinoxaline

HRID 1576012노트

반응식

HRID 1576012 반응식
[N:1]1[N:5]2[C:6]3[C:11]([N:12]=[CH:13][C:4]2=[N:3][N:2]=1)=[CH:10][CH:9]=[CH:8][CH:7]=3.C.[H][H]>C(O)C>[N:1]1[N:5]2[C:6]3[C:11]([NH:12][CH2:13][C:4]2=[N:3][N:2]=1)=[CH:10][CH:9]=[CH:8][CH:7]=3

참가 물질

5

반응물 3

HCID 297MethaneHCID 10103592HCID 10103592, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 215140494,5-Dihydrotetrazolo[1,5-a]quinoxaline수율 45%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A 1 g. portion of tetrazolo[1,5-a]quinoxaline was dissolved in 200 ml. of ethanol. The solution was placed in a Parr hydrogenator on a shaking apparatus and 100 mg. of 5 percent palladized charcoal was added. The bomb was pressurized to about 2 atmospheres with hydrogen and was shaken for 2 hours. The reaction mixture was then removed and filtered. The filtrate was evaporated to dryness and the residue was recrystallized from ethanol-water to obtain the product, 4,5-dihydrotetrazolo[1,5-a]quinoxaline, m.p. 149°-51°C., in 45 percent yield. The product was identified by nuclear magnetic resonance analysis and by elemental microanalysis, with the following results.

후처리

  1. additionwas added
  2. customThe reaction mixture was then removed
  3. filtrationfiltered
  4. customThe filtrate was evaporated to dryness
  5. customthe residue was recrystallized from ethanol-water

출처 및 근거

ORD 기록
ord-bd0f956c3b6b459aaedcceb9ea95ca2e
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03979387

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