Diethyl (ethoxymethylene)malonate → [[[1-(2-Furyl)methyl-5-pyrazolyl]amino]methylene]malonic acid diethyl ester

HRID 1576088노트

반응식

HRID 1576088 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]1[C:11]([NH2:12])=[CH:10][CH:9]=[N:8]1.[CH2:13]([O:15][C:16](=[O:27])[C:17](=[CH:23]OCC)[C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:14]>>[CH2:13]([O:15][C:16](=[O:27])[C:17](=[CH:23][NH:12][C:11]1[N:7]([CH2:6][C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)[N:8]=[CH:9][CH:10]=1)[C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:14]

참가 물질

3

반응물 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 25461821-(furan-2-ylmethyl)-1H-pyrazol-5-amine

생성물 1

HCID 68131587[[[1-(2-Furyl)methyl-5-pyrazolyl]amino]methylene]malonic acid diethyl ester

실험 절차

163 g of 1-(2-furyl)methyl-5-aminopyrazole (1mol) and 216 g of ethoxymethylene malonic acid diethyl ester (1 mol) are heated to 130° (bath temperature) until the theoretical amount of alcohol is distilled off. The remaining oil, [[[1-(2-furyl)methyl-5-pyrazolyl]aino]methylene]malonic acid diethyl ester, is recrystallized from methanol, yield 280 g (84%), m.p. 84°-86°.

후처리

  1. distillationis distilled off
  2. customThe remaining oil, [[[1-(2-furyl)methyl-5-pyrazolyl]aino]methylene]malonic acid diethyl ester, is recrystallized from methanol, yield 280 g (84%), m.p. 84°-86°

출처 및 근거

ORD 기록
ord-b26c8060166c4543bb060eb89364f663
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03979399

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