Dimethylcarbamoyl Chloride → alpha-Diethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid

HRID 1576250

반응식

HRID 1576250 반응식
[CH2:1]([N:3]([CH2:7][CH3:8])[C:4](Cl)=[O:5])[CH3:2].C(Cl)(=O)N.C(NC(Cl)=O)C.CN(C)C(Cl)=O.C([S:28][CH:29]([C:33]1[CH:38]=[CH:37][C:36]([CH:39]2[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]2)=[C:35]([Cl:45])[CH:34]=1)[C:30]([OH:32])=[O:31])(=O)N.C(NC(SC(C1C=CC(C2CCCCC2)=C(Cl)C=1)C(O)=O)=O)C.CN(C)C(SC(C1C=CC(C2CCCCC2)=C(Cl)C=1)C(O)=O)=O>>[CH2:1]([N:3]([CH2:7][CH3:8])[C:4]([S:28][CH:29]([C:33]1[CH:38]=[CH:37][C:36]([CH:39]2[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44]2)=[C:35]([Cl:45])[CH:34]=1)[C:30]([OH:32])=[O:31])=[O:5])[CH3:2]

참가 물질

8

반응물 7

HCID 6598Dimethylcarbamoyl ChlorideHCID 6916Diethylcarbamoyl chlorideHCID 68048Carbamic chlorideHCID 12321963N-ethylcarbamoyl chlorideHCID 21514611alpha-Dimethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acidHCID 21514616alpha-Carbamylthio-3-chloro-4-cyclohexylphenylacetic acidHCID 86733940alpha-Ethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid

생성물 1

HCID 21514613alpha-Diethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid

실험 절차

When diethylcarbamylchloride is replaced in the above procedure by carbamyl chloride (prepared in situ from potassium cyanate and anhydrous hydrogen chloride in anhydrous chloroform), ethylcarbamyl chloride or dimethylcarbamyl chloride, then the products prepared are α-carbamylthio-3-chloro-4-cyclohexylphenylacetic acid, α-ethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid or α-dimethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid.

후처리

  1. customthe products prepared

출처 및 근거

ORD 기록
ord-92c1e3e7e8c844cd84ce9c0ca68eed92
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03979428

연결된 노트

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