4-Piperidinol, 1-(1H-indol-3-yloxoacetyl)-4-phenyl- → HCID 12589402, 화합물

HRID 1576485노트

반응식

HRID 1576485 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10](=O)[C:11]([N:13]2[CH2:18][CH2:17][C:16]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)([OH:19])[CH2:15][CH2:14]2)=O)=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[OH:19][C:16]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:15][CH2:14][N:13]([CH2:11][CH2:10][C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:18][CH2:17]1

참가 물질

4

반응물 2

HCID 2055944-Piperidinol, 1-(1H-indol-3-yloxoacetyl)-4-phenyl-HCID 21226445Aluminium lithium hydride

생성물 1

HCID 12589402HCID 12589402, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 17.0 g. (0.049 mole) of 1-(indol-3-ylglyoxyloyl)-4-phenyl-4-piperidinol in 100 ml. of tetrahydrofuran was reduced in the usual way with 7.4 g. (0.195 mole) of lithium aluminum hydride in 200 ml. of tetrahydrofuran. After the usual workup 11.6 g. of oil was obtained which was crystallized from benzene-isooctane yielding 8.6 g. (55%) of product which melted at 133°-137° C. Another recrystallization from benzene raised the melting point to 137°-139° C. The analytical sample melted at 137°-139° C.

후처리

  1. customof oil was obtained which
  2. customwas crystallized from benzene-isooctane yielding 8.6 g
  3. customAnother recrystallization from benzene
  4. temperatureraised the melting point to 137°-139° C

출처 및 근거

ORD 기록
ord-8a2e53330eaf4964a3f569b999ddd63b
출처 데이터셋
uspto-grants-1976_09
특허 번호
USRE028973

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