Bromine → 5-Bromo-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

HRID 1576490

반응식

HRID 1576490 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1.[Br:13]Br>O>[Br:13][C:4]1[C:5](=[O:10])[NH:6][C:7](=[O:9])[NH:8][C:3]=1[C:2]([F:1])([F:11])[F:12]

참가 물질

4

반응물 2

HCID 24408BromineHCID 2338906-(Trifluoromethyl)uracil

생성물 1

HCID 215107845-Bromo-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

시약·촉매·용매 1

HCID 962Water용매

실험 절차

6-(Trifluoromethyl)uracil (4.0 g., 0.22 mole) was dissolved in 75 ml. water at 70°C. Bromine (3.55 g., 0.022 mole) was added in portions with vigorous stirring. A white precipitate formed almost immediately. The suspension was allowed to cool to room temperature and then chilled before being filtered. The product after air drying weighed 4.75 g. (82.5%) and had a melting point of 231°-234°C. The analytical sample melting point was 236°-240°C. After recrystallization from water.

후처리

  1. customat 70°C
  2. customA white precipitate formed almost immediately
  3. temperaturechilled
  4. filtrationbefore being filtered
  5. customThe product after air drying
  6. customAfter recrystallization from water

출처 및 근거

ORD 기록
ord-74e169e1834541b9833e90091bca3303
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03981715

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