Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isovincamine → Vincamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isovincamine | HCID 5668 | — |
| 반응물 | Tetrabutylammonium Hydroxide | HCID 2723671 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Vincamine | HCID 15376 | 36% |
반응 단계
If the isomerisation of 16-epivincamine described in Example 4 is repeated but using 177 mg. (0.5 millimole) of 16-epivincamine in 20 ml. of methanol and 130 mg. (0.2 millimole) of a 40% aqueous solution of tetrabutylammonium hydroxide (formula (I)b), and the mixture is allowed to stand for 5 hours at 25°C. 64 mg. of vincamine are obtained (yield 36%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03982002 |
| 출처 데이터셋 | uspto-grants-1976_09 |
| ORD ID | ord-9012b34a41504efb94d4b4cd7605aaec |
| 출처 메모 | uspto-grants-1976_09 |