Citric Acid → HCID 86734022, 화합물

HRID 1576775노트

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HRID 1576775 반응식
[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2].[C:34]([OH:46])(=[O:45])[CH2:35][C:36]([CH2:41][C:42]([OH:44])=[O:43])([C:38]([OH:40])=[O:39])[OH:37]>C(O)C>[C:34]([OH:46])(=[O:45])[CH2:35][C:36]([CH2:41][C:42]([OH:44])=[O:43])([C:38]([OH:40])=[O:39])[OH:37].[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2]

참가 물질

4

반응물 2

HCID 311Citric AcidHCID 86734023HCID 86734023, 화합물

생성물 1

HCID 86734022HCID 86734022, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (0.093 g, 0.2 mmole) in ethanol (1 ml) was treated with a 0.1M solution of citric acid (2 ml, 0.2 mmole) at room temperature. The clear solution was immediately evaporated to dryness at room temperature and redissolved in distilled water (ca. 5 ml). The aqueous solution was stored at 0° overnight and then filtered. The solid collected was washed with distilled water (ca. 1 ml) and the washings and filtrate combined. The residue was dissolved in chloroform and evaporated under vacuum to constant weight (0.0016 g). The filtrate and washings were made up to 9.14 ml with distilled water thereby giving a solution of title compound (pH 3.59) at concentration 10 mg/ml with respect to steroid.

후처리

  1. customThe clear solution was immediately evaporated to dryness at room temperature
  2. dissolutionredissolved in distilled water (ca. 5 ml)
  3. filtrationfiltered
  4. customThe solid collected
  5. washwas washed with distilled water (ca. 1 ml)
  6. dissolutionThe residue was dissolved in chloroform
  7. customevaporated under vacuum to constant weight (0.0016 g)

출처 및 근거

ORD 기록
ord-c2adaabddf3547158f1260d40af527ca
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03983111

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