21-Morpholino-5alpha-pregnane-3,11,20-trione → 3alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione

HRID 1576784노트

반응식

HRID 1576784 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8](=[O:30])[C@@H:9]2[C@:26]3([CH3:27])[C@H:12]([C@H:13]4[C@H:23]([C:24](=[O:28])[CH2:25]3)[C@:21]3([CH3:22])[C@H:16]([CH2:17][C:18](=[O:29])[CH2:19][CH2:20]3)[CH2:15][CH2:14]4)[CH2:11][CH2:10]2)[CH2:3][CH2:2]1>O>[OH:29][C@@H:18]1[CH2:19][CH2:20][C@@:21]2([CH3:22])[C@@H:16]([CH2:15][CH2:14][C@@H:13]3[C@@H:23]2[C:24](=[O:28])[CH2:25][C@@:26]2([CH3:27])[C@H:12]3[CH2:11][CH2:10][C@@H:9]2[C:8](=[O:30])[CH2:7][N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[CH2:17]1

참가 물질

3

반응물 1

HCID 8673403221-Morpholino-5alpha-pregnane-3,11,20-trione

생성물 1

HCID 867340213alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 21-morpholino-5α-pregnane-3,11,20-trione (100 mg.) in the "stock" hloroiridic solution (see preparation 6 below) (10 ml.), was refluxed for 14 hours. The cooled mixture was poured into water and made just alkaline. The slight oily precipitate was extracted into ethyl acetate and the extracts were washed with water, dried (Na2SO4), and evaporated to give essentially the title compound, shown by n.m.r. spectroscopy and T.L.C. (Rf 0.16) on silica in ethyl acetate to be identical to the product of Example 38.

후처리

  1. temperaturewas refluxed for 14 hours
  2. extractionThe slight oily precipitate was extracted into ethyl acetate
  3. washthe extracts were washed with water
  4. dry with materialdried (Na2SO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-6af6eaab32cb46feb5e8f3970243b299
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03983111

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