Citric Acid → HCID 86734022, 화합물

HRID 1576786노트

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HRID 1576786 반응식
[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2].[C:34]([OH:46])(=[O:45])[CH2:35][C:36]([CH2:41][C:42]([OH:44])=[O:43])([C:38]([OH:40])=[O:39])[OH:37]>C(O)C>[C:34]([OH:46])(=[O:45])[CH2:35][C:36]([CH2:41][C:42]([OH:44])=[O:43])([C:38]([OH:40])=[O:39])[OH:37].[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2]

참가 물질

4

반응물 2

HCID 311Citric AcidHCID 86734023HCID 86734023, 화합물

생성물 1

HCID 86734022HCID 86734022, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (0.93 g.) in ethanol (1 ml.) was treated with a 0.1 M solution of citric acid (20 ml.) at room temperature. The solution was evaporated to dryness and redissolved in distilled water (5 ml.). The resulting solution was filtered and the collected residue was washed with water (1 ml.). The filtrate and washings were made up to 9.2 ml with distilled water thereby giving a solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione citrate at concentration 100 mg./ml. with respect to steroid (pH 3.5).

후처리

  1. customThe solution was evaporated to dryness
  2. dissolutionredissolved in distilled water (5 ml.)
  3. filtrationThe resulting solution was filtered
  4. washthe collected residue was washed with water (1 ml.)

출처 및 근거

ORD 기록
ord-eb21d54d283449a59487cd40719d516f
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03983111

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