참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzene | HCID 241 | — |
| 반응물 | O-Xylene | HCID 7237 | — |
| 반응물 | 2-Amino-1-(4-fluorophenyl)ethan-1-ol | HCID 9827 | — |
| 반응물 | 2-Nitroamino-2-imidazoline | HCID 410042 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | p-Fluoro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol | HCID 54097200 | — |
반응 단계
To a solution of 6.5 parts of α-(aminomethyl)-p-fluorobenzyl alcohol in 8 parts of xylene are added 5.2 parts of 2-(nitramino)-2-imidazoline. The mixture is heated in an oil-bath to about 160°C. till gas-evolution is ceased (about 15 minutes). The reaction mixture is cooled and treated with benzene and acetone. The product is sucked off and crystallized from 4-methyl-2-pentanone, yielding p-fluoro-α-(2-imidazolin-2-ylaminomethyl)benzyl alcohol; m.p. 153.4°C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US03983133 |
|---|
| 출처 데이터셋 | uspto-grants-1976_09 |
|---|
| ORD ID | ord-5e07924bcc1c4a1786b6b7b727016d36 |
|---|
| 출처 메모 | uspto-grants-1976_09 |
|---|
