4-Chloro-2-toluidine → 3-(2-Methyl-4-chloroanilino)propionaldehyde

HRID 1576940노트

반응식

HRID 1576940 반응식
[CH3:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH2:4].Br[CH:11]([CH3:14])[CH:12]=[O:13].C(=O)([O-])[O-].[Na+].[Na+]>>[CH3:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH:4][CH2:14][CH2:11][CH:12]=[O:13]

참가 물질

4

반응물 3

HCID 72514-Chloro-2-toluidineHCID 10340Sodium CarbonateHCID 3506242-Bromopropanal

생성물 1

HCID 215102843-(2-Methyl-4-chloroanilino)propionaldehyde

반응 조건

온도
150 °C

실험 절차

2-Methyl-4-chloroaniline (1.0 mole), the diethyl acetal of 2-bromopropionaldehyde (1.0 mole) and sodium carbonate (1.0 mole) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The mixture is heated at a temperature of about 150°C for a period of about 24 hours. After this time the reaction mixture is cooled to room temperature and is filtered. The filtrate is then distilled under vacuum to yield the desired product the diethyl acetal of 3-(2-methyl-4-chloroanilino)propionaldehyde as the residue.

후처리

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureAfter this time the reaction mixture is cooled to room temperature
  4. filtrationis filtered
  5. distillationThe filtrate is then distilled under vacuum

출처 및 근거

ORD 기록
ord-f33261b76033415585048cf73267c0af
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03983174

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