2-Methoxyethanol → Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-

반응식

Cl.Cl[CH2:3][CH2:4][N:5]([CH2:9][CH2:10]Cl)[CH2:6][CH2:7]Cl.[CH3:12][O:13][CH2:14][CH2:15][OH:16]>>[CH2:4]([N:5]([CH2:9][CH2:10][O:16][CH2:15][CH2:14][O:13][CH3:12])[CH2:6][CH2:7][O:16][CH2:15][CH2:14][O:13][CH3:12])[CH2:3][O:16][CH2:15][CH2:14][O:13][CH3:12]

참가 물질

반응물 2

HCID 80192-Methoxyethanol

HCID 61220Tris(2-chloroethyl)amine hydrochloride

생성물 1

HCID 112414Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-

실험 절차

51.6 g (namely, 0.215 mol) of tris-(2-chloroethyl)-amine hydrochloride were added to the above mixture. The mixture was subsequently heated at the reflux temperature of the 2-methoxyethanol (125° C.) for 12 hours and the solvent was then distilled under reduced pressure. The excess sodium 2-methoxyethanolate was neutralized by adding 11.6 cm3 of aqueous HCl (10 N). The sodium chloride was filtered off and the solution was distilled.

후처리

distillationthe solvent was then distilled under reduced pressure
additionby adding 11.6 cm3 of aqueous HCl (10 N)
filtrationThe sodium chloride was filtered off
distillationthe solution was distilled

출처 및 근거

ORD 기록: ord-af468309fbbb4460a9d40217fa30154c
출처 데이터셋: uspto-grants-1981_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04287125

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