Ethylamine → HCID 178464569, 화합물

HRID 1577176노트

반응식

HRID 1577176 반응식
[CH2:1]([NH2:3])[CH3:2].[C:4]([NH:6][C:7](=[N:10][CH2:11][CH2:12][S:13][CH2:14][C:15]1[NH:19][CH:18]=[N:17][C:16]=1[CH3:20])SC)#[N:5]>C(O)C>[C:4]([NH:6][C:7]([NH:3][CH2:1][CH3:2])=[N:10][CH2:11][CH2:12][S:13][CH2:14][C:15]1[NH:19][CH:18]=[N:17][C:16]=1[CH3:20])#[N:5]

참가 물질

4

반응물 2

HCID 6341EthylamineHCID 178503877HCID 178503877, 화합물

생성물 1

HCID 178464569HCID 178464569, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Anhydrous ethylamine (9.0 g.) was added to a solution of N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea (Example 3(c), 5.0 g.) in ethanol. The solution was heated under reflux for 8 hours and concentrated under reduced pressure. The residue was dissolved in isopropyl alcohol, filtered, and diluted with water. The white solid obtained was recrystallised from isopropyl alcohol-ether to yield N-cyano-N'-ethyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine, m.p. 118°-120°. (Found: C, 49.6; H, 6.8; N, 31.2; S, 11.7. C11H18N6S requires: C, 49.6; H, 6.8; N, 31.6; S, 12.0).

후처리

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 8 hours
  3. concentrationconcentrated under reduced pressure
  4. dissolutionThe residue was dissolved in isopropyl alcohol
  5. filtrationfiltered
  6. additiondiluted with water
  7. customThe white solid obtained
  8. customwas recrystallised from isopropyl alcohol-ether

출처 및 근거

ORD 기록
ord-d6406bc63b7b4500b9d546936df0cfac
출처 데이터셋
uspto-grants-1981_09
특허 번호
US04287198

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