3-[(2-Aminoethyl)thiomethyl]pyridazine → N-nitro-N'-[2-(3-pyridazinylmethylthio)ethyl)guanidine

반응식

[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:7]=[N:8][CH:9]=[CH:10][CH:11]=1.CS[C:14](=[NH:19])[NH:15][N+:16]([O-:18])=[O:17]>>[N+:16]([NH:15][C:14]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:7]=[N:8][CH:9]=[CH:10][CH:11]=1)=[NH:19])([O-:18])=[O:17]

참가 물질

반응물 2

HCID 202425053-[(2-Aminoethyl)thiomethyl]pyridazine

HCID 135927615N-Nitro-S-methylisothiourea

생성물 1

HCID 178512217N-nitro-N'-[2-(3-pyridazinylmethylthio)ethyl)guanidine

실험 절차

Reaction of 3-[(2-aminoethyl)thiomethyl]pyridazine with S-methyl-N-nitroisothiourea by the procedure of Example 2(ii) gives N-nitro-N'-[2-(3-pyridazinylmethylthio)ethyl]guanidine. Similarly, by the procedure of Example 2(iii), there is obtained N-methyl-N'-nitro-N"-[2-(3-pyridazinylmethylthio)ethyl]guanidine.

출처 및 근거

ORD 기록: ord-062ad81c471a40bebede64a582713315
출처 데이터셋: uspto-grants-1981_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04287198

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