Water → HCID 20570918, 화합물

HRID 1577501노트

반응식

HRID 1577501 반응식
[CH3:1][N:2]([CH3:13])[C:3]([C:5]1[O:6][CH:7]=[CH:8][C:9]=1[CH:10]([CH3:12])[CH3:11])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[CH3:1][N:2]([CH3:13])[CH2:3][C:5]1[O:6][CH:7]=[CH:8][C:9]=1[CH:10]([CH3:11])[CH3:12]

참가 물질

5

반응물 3

HCID 962WaterHCID 20570904HCID 20570904, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 20570918HCID 20570918, 화합물수율 63.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of N,N-dimethyl-3-(1-methylethyl)-2-furanecarboxamide (12 g) in dry tetrahydrofuran (250 ml) was treated with lithium aluminium hydride (4.2 g). After 1 hour water (6 ml) was added and the filtered solution evaporated in vacuo. The residue was dissolved in 1 M hydrochloric acid (100 ml) and the solution was washed with diethyl ether (100 ml). The aqueous phase was basified and extracted with diethyl ether (2×150 ml), which was dried over anhydrous sodium sulphate. The solvent was removed in vacuo to yield the title compound (7 g) as an oil.

후처리

  1. customthe filtered solution evaporated in vacuo
  2. dissolutionThe residue was dissolved in 1 M hydrochloric acid (100 ml)
  3. washthe solution was washed with diethyl ether (100 ml)
  4. extractionextracted with diethyl ether (2×150 ml), which
  5. dry with materialwas dried over anhydrous sodium sulphate
  6. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-6b820ed1807f445c9f19370f85f509f3
출처 데이터셋
uspto-grants-1981_09
특허 번호
US04288443

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