Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → 5-(Dimethylaminomethyl)-4-methyl-2-furanmethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Dimethylaminomethyl-3-methylfuran | HCID 10034749 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 5-(Dimethylaminomethyl)-4-methyl-2-furanmethanol | HCID 20570909 | 63.9% |
반응 단계
A solution of N,N,3-trimethyl-2-furanmethanamine (10.3 g) in dry tetrahydrofuran (200 ml) under nitrogen was treated over 2 hr with 1.6 M n-butyl lithium in hexane 846.2 ml) at -40° to -45° C. After stirring for 2 hr at room temperature paraformaldehyde (2.3 g) in dry tetrahydrofuran (100 ml) was added and the solution stirred overnight. Water (10 ml) was added and the solvent evaporated. Ethyl acetate (200 ml) and sodium sulphate were added and the organic phase was evaporated giving an oily residue which was distilled (85°/0.1 mm) affording the title compound (8 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04288443 |
| 출처 데이터셋 | uspto-grants-1981_09 |
| ORD ID | ord-52f9c2e5704e4df9816d527246f83d59 |
| 출처 메모 | uspto-grants-1981_09 |