Ammonia → HCID 178510717, 화합물

HRID 1577546

반응식

HRID 1577546 반응식
[C:1]([C:9]1[S:13][C:12]2[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=2[C:10]=1[OH:18])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:19]>O>[NH2:19]/[C:1](/[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[C:9]1\[C:10](=[O:18])[C:11]2[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=2[S:13]\1

참가 물질

4

반응물 2

HCID 222Ammonia2회HCID 4712192Methanone, (3-hydroxybenzo[b]thien-2-yl)phenyl-

생성물 1

HCID 178510717HCID 178510717, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

A mixture of 10.0 gm (0.0393 mol) of 2-benzoylbenzo[b]-thiophen-3-ol, 60 cc of concentrated aqueous ammonia and 250 cc of ethanol was heated for 20 hours at a temperature of 120° C. after introducing 5 bar of ammonia gas into the vessel. After cooling, the mixture was stirred into 1.5 liters of water, the precipitated pale yellow reaction product was filtered off with suction, washed thoroughly several times with 50 cc each of water and dried in the air. 4.23 gm (42% of theory) of yellow crystals, m.p. 121°-122° C., were obtained (after twice recrystallizing from petroleum ether/ethyl acetate 1:1 using activated carbon) and were found to be completely identical with the product obtained in Example 1 based on elemental analysis, IR and UV spectra.

후처리

  1. temperatureAfter cooling
  2. filtrationthe precipitated pale yellow reaction product was filtered off with suction
  3. washwashed thoroughly several times with 50 cc each of water
  4. customdried in the air
  5. custom4.23 gm (42% of theory) of yellow crystals, m.p. 121°-122° C., were obtained (
  6. customafter twice recrystallizing from petroleum ether/ethyl acetate 1:1 using activated carbon) and

출처 및 근거

ORD 기록
ord-5d388c9bf3fc411c8812ac7ceb401c01
출처 데이터셋
uspto-grants-1981_09
특허 번호
US04288437

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