Propargylamine → 1-Cyano-2-(2-propynylamino)-2-{2-[(3-chloro-2-pyridyl)methylthio]ethylamino}ethylene

HRID 1577921노트

반응식

HRID 1577921 반응식
Cl[C:2]1[C:3](CSCCN)=[N:4]C=C[CH:7]=1.C(C=C(OC)OC)#N.[C:21]([CH:23]=[C:24](OC)[NH:25][CH2:26][CH2:27][S:28][CH2:29][C:30]1[C:35]([Cl:36])=[CH:34][CH:33]=[CH:32][N:31]=1)#[N:22].C(N)C#C>>[C:21]([CH:23]=[C:24]([NH:4][CH2:3][C:2]#[CH:7])[NH:25][CH2:26][CH2:27][S:28][CH2:29][C:30]1[C:35]([Cl:36])=[CH:34][CH:33]=[CH:32][N:31]=1)#[N:22]

참가 물질

5

반응물 4

HCID 239041PropargylamineHCID 129515322-(3-Chloropyrid-2-ylmethylthio)ethylamineHCID 226227003,3-Dimethoxyprop-2-enenitrileHCID 705721731-Cyano-2-methoxy-2-[2-((3-chloro-2-pyridyl)methylthio)ethylamino]ethylene

생성물 1

HCID 736839881-Cyano-2-(2-propynylamino)-2-{2-[(3-chloro-2-pyridyl)methylthio]ethylamino}ethylene

실험 절차

When 2-[(3-chloro-2-pyridyl)methylthio]ethylamine is reacted with 1-cyano-2,2-bis(methoxy)ethylene and the resultant 1-cyano-2-methoxy-2-{2-[(3-chloro-2-pyridyl)methylthio]ethylamino}ethylene is reacted with propargylamine according to the general procedure of Example 1 Step B the title compound is produced.

출처 및 근거

ORD 기록
ord-f21b1572311844c3bc33edc9b18a7240
출처 데이터셋
uspto-grants-1981_09
특허 번호
US04289876

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