1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → Pregna-4,16-diene-3,20-dione

HRID 1578023

반응식

HRID 1578023 반응식
C(O[C@:9]1([C@:29]2([CH3:30])[C@H:15]([C@H:16]3[C@H:26]([CH2:27][CH2:28]2)[C@:24]2([CH3:25])[C:19](=[CH:20][C:21](=[O:31])[CH2:22][CH2:23]2)[CH2:18][CH2:17]3)[CH2:14][CH2:13]1)[C:10](=[O:12])[CH3:11])(=O)CCCCC.C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>>[CH3:11][C:10](=[O:12])[C:9]1[C@:29]2([CH3:30])[C@H:15]([C@H:16]3[C@H:26]([CH2:27][CH2:28]2)[C@:24]2([CH3:25])[C:19](=[CH:20][C:21](=[O:31])[CH2:22][CH2:23]2)[CH2:18][CH2:17]3)[CH2:14][CH:13]=1

참가 물질

3

반응물 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 169870Hydroxyprogesterone Caproate

생성물 1

HCID 101964Pregna-4,16-diene-3,20-dione수율 83%

실험 절차

One gram of 17α-hexanoyloxy-4pregnene-3,20-dione is heated analogously to Example 1 in "Dowtherm" for 80 minutes to 285° C., worked up, separated, and combined. Recrystallization from ethanol yields 600 mg of 4,16-pregnadiene-3,20-dione (83% of theory), m.p. 185°-190° C.

후처리

  1. customseparated
  2. customRecrystallization from ethanol

출처 및 근거

ORD 기록
ord-c3f69325bb174eaa9e16edc3a966420d
출처 데이터셋
uspto-grants-1981_09
특허 번호
US04290963

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