Formaldehyde → 2-(1-[Indol-3-ylmethyl]piperid-4-yl)-1H-isoindole-1,3-(2H)-dione

HRID 1578110노트

반응식

HRID 1578110 반응식
C=O.[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4]1.Cl.[NH:13]1[CH2:18][CH2:17][CH:16]([N:19]2[C:27](=[O:28])[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[C:20]2=[O:29])[CH2:15][CH2:14]1.[C:30]([O-])(=O)C.[Na+]>C(O)(=O)C.O>[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH2:30][N:13]2[CH2:18][CH2:17][CH:16]([N:19]3[C:20](=[O:29])[C:21]4[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:27]3=[O:28])[CH2:15][CH2:14]2)=[CH:4]1

참가 물질

7

반응물 4

HCID 712FormaldehydeHCID 798IndoleHCID 517045Sodium AcetateHCID 218825602-(Piperidin-4-yl)isoindoline-1,3-dione hydrochloride

생성물 1

HCID 205688982-(1-[Indol-3-ylmethyl]piperid-4-yl)-1H-isoindole-1,3-(2H)-dione

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

Formaldehyde (0.84 cm3, 40% aq. w/v, 11.3 mmol) was added to a stirred and cooled mixture of indole (1.32 g, 11.3 mmol), 2-(piperid-4-yl)-1H-isoindol-1,3-(2H)-dione, hydrochloride (3.0 g, 11.3 mmol), and sodium acetate (0.93 g, 11.3 mmol) in glacial acetic acid (10 cm3). The suspension was stirred at room temperature for 5 hours, then poured into water and a gummy precipitate filtered off. The mother liquors were basified by addition of 0.880 ammonia to precipitate the title compound, which was collected and dried (2.52 g, 62.4%).

후처리

  1. temperaturecooled
  2. stirringThe suspension was stirred at room temperature for 5 hours
  3. filtrationa gummy precipitate filtered off
  4. additionThe mother liquors were basified by addition of 0.880 ammonia
  5. customto precipitate the title compound, which
  6. customwas collected
  7. customdried (2.52 g, 62.4%)

출처 및 근거

ORD 기록
ord-1eb450068dfb450db327d477248e24e9
출처 데이터셋
uspto-grants-1981_09
특허 번호
US04291042

반응 노트

불러오는 중…