N-Carbobenzyloxy-4-hydroxy-4-[(4-pyridyl)methyl]-L-prolin → 4-hydroxy-4-[(4-pyridyl)methyl]-L-proline

HRID 1578146노트

반응식

HRID 1578146 반응식
C([N:11]1[CH2:18][C:17]([OH:26])([CH2:19][C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[CH2:16][C@H:12]1[C:13]([OH:15])=[O:14])(OCC1C=CC=CC=1)=O.C(SC1(C(O)=O)C(C(=O)C)=CCN1CC1OC=CC=1)(=O)C>>[OH:26][C:17]1([CH2:19][C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[CH2:18][NH:11][C@H:12]([C:13]([OH:15])=[O:14])[CH2:16]1

참가 물질

3

반응물 2

HCID 53928413N-Carbobenzyloxy-4-hydroxy-4-[(4-pyridyl)methyl]-L-prolin2회HCID 867380162-(Acetylthio)-1-oxoethyl-[(2-furyl)methyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acid

생성물 1

HCID 539451174-hydroxy-4-[(4-pyridyl)methyl]-L-proline

실험 절차

The N-carbobenzyloxy-4-hydroxy-4-[(4-pyridyl)methyl]-L-proline from part (a) is hydrogenated according to the procedure of Example 1 (b) to yield 4-hydroxy-4-[(4-pyridyl)methyl]-L-proline. This amino acid is reacted with D-3-acetylthio-2-methylpropionyl chloride according to the procedure of Example 1 (c) to yield [1(S)]-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-4-hydroxy-4-[(4-pyridyl)methyl]-L-proline.

출처 및 근거

ORD 기록
ord-23f635913e074178bf32fe417ef8bf85
출처 데이터셋
uspto-grants-1981_09
특허 번호
US04291040

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