Methoxydiphenylphosphine → 2,4,6-Trimethylbenzoyl diphenylphosphine oxide

HRID 1578229

반응식

HRID 1578229 반응식
C[O:2][P:3]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:16][C:17]1[CH:25]=[C:24]([CH3:26])[CH:23]=[C:22]([CH3:27])[C:18]=1[C:19](Cl)=[O:20]>CCOCC>[CH3:16][C:17]1[CH:25]=[C:24]([CH3:26])[CH:23]=[C:22]([CH3:27])[C:18]=1[C:19]([P:3](=[O:2])([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:20]

참가 물질

4

반응물 2

HCID 77636MethoxydiphenylphosphineHCID 970382,4,6-Trimethylbenzoyl chloride

생성물 1

HCID 1664802,4,6-Trimethylbenzoyl diphenylphosphine oxide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
50 °C

실험 절차

648 parts of methoxydiphenylphosphine are added slowly to 547.5 parts of 2,4,6-trimethylbenzoyl chloride at 50°-95° C. in a stirred apparatus equipped with a reflux condenser and dropping funnel. The mixture is then stirred for 4-5 hours at 50° C., the contents of the flask are dissolved in ether at 30° C., and petroleum ether is added until the mixture starts to turn cloudy. On cooling, 910 parts (87% of theory) of 2,4,6-trimethylbenzoyl-diphenylphosphine oxide crystallize. Pale yellow crystals, melting point 89°-92° C.

후처리

  1. customequipped with a reflux condenser
  2. temperatureOn cooling
  3. custom910 parts (87% of theory) of 2,4,6-trimethylbenzoyl-diphenylphosphine oxide crystallize

출처 및 근거

ORD 기록
ord-87499e0f9f7e4d37a573d3b89ef59088
출처 데이터셋
uspto-grants-1981_09
특허 번호
US04292152

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