Hydrazinecarboxaldehyde → Hydrazinecarbothioamide, N-(2-fluorophenyl)-2-formyl-

HRID 1578524노트

반응식

HRID 1578524 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[S:10].[CH:11]([NH:13][NH2:14])=[O:12]>O1CCCC1>[CH:11]([NH:13][NH:14][C:9]([NH:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])=[S:10])=[O:12]

참가 물질

4

반응물 2

HCID 12229HydrazinecarboxaldehydeHCID 975202-Fluorophenyl isothiocyanate

생성물 1

HCID 2390670Hydrazinecarbothioamide, N-(2-fluorophenyl)-2-formyl-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Fifty grams (0.33 mole) of 2-fluorophenylisothiocyanate and 20 g. (0.33 mole) of formylhydrazine were refluxed for 7 hours in 500 ml. of tetrahydrofuran (THF). The reaction mixture was allowed to cool and the insoluble product was collected by filtration. The crude product was washed with water, filtered and dried. The yield was 10 g. of 1-formyl-4-(2-fluorophenyl)-3-thiosemicarbazide, mp. about 148°-149°C.

후처리

  1. temperatureto cool
  2. filtrationthe insoluble product was collected by filtration
  3. washThe crude product was washed with water
  4. filtrationfiltered
  5. customdried

출처 및 근거

ORD 기록
ord-6cee509447044c32861c8aed90214aec
출처 데이터셋
uspto-grants-1976_02
특허 번호
US03937713

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