Acetohydrazide → HCID 12207321, 화합물

HRID 1578525노트

반응식

HRID 1578525 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]=[C:10]=[S:11].[C:12]([NH:15][NH2:16])(=[O:14])[CH3:13]>C1COCC1>[C:12]([NH:15][NH:16][C:10]([NH:9][C:3]1[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=1[Cl:1])=[S:11])(=[O:14])[CH3:13]

참가 물질

4

반응물 2

HCID 14039AcetohydrazideHCID 227520811-Chloro-2-isothiocyanato-4-methylbenzene

생성물 1

HCID 12207321HCID 12207321, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

One tenth mole, 18.3 g., of 2-chloro-5-methylphenylisothiocyanate and 11.0 g. (0.15 mole) of acetylhydrazine were refluxed for 7 hours in 500 ml. of THF. After cooling, the insoluble product was collected by filtration. The crude product was collected by filtration. The crude product was washed with water, filtered and dried. The yield was 25 g. of 1-acetyl-4-(2-chloro-5-methylphenyl)-3-thiosemicarbazide, m.p. about 145°-157°C.

후처리

  1. temperatureAfter cooling
  2. filtrationthe insoluble product was collected by filtration
  3. filtrationThe crude product was collected by filtration
  4. washThe crude product was washed with water
  5. filtrationfiltered
  6. customdried

출처 및 근거

ORD 기록
ord-f7ce56690b79492bbcd3f8d93e8101d4
출처 데이터셋
uspto-grants-1976_02
특허 번호
US03937713

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