Acetic Acid → 1-(4-methoxy-2-nitrophenyl)-1H-pyrrole
반응식
CO[CH:3]1[CH2:7][CH2:6][CH:5](OC)O1.[CH3:10][O:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[C:14]([N+:19]([O-:21])=[O:20])[CH:13]=1.C(O)(=O)C.[OH-].[K+]>O>[CH3:10][O:11][C:12]1[CH:18]=[CH:17][C:15]([N:16]2[CH:3]=[CH:7][CH:6]=[CH:5]2)=[C:14]([N+:19]([O-:21])=[O:20])[CH:13]=1참가 물질
6
실험 절차
100 g (0.75 mole) of 2,5-dimethoxytetrahydrofuran are added to a solution of 84.1 g (0.5 mole) of 4-methoxy-2-nitroaniline in 500 ml. of glacial acetic acid. The solution is refluxed for 30 minutes, poured into 2500 ml. of water, and neutralized with potassium hydroxide. A solid precipitates and is filtered, dried, and recrystallized from ether to give 1-(4-methoxy-2-nitrophenyl)pyrrole, m.p. 75.5°-76.5° C.
후처리
- temperatureThe solution is refluxed for 30 minutes
- additionpoured into 2500 ml
- customA solid precipitates
- filtrationis filtered
- customdried
- customrecrystallized from ether
출처 및 근거
- ORD 기록
- ord-ca975fabc1e94650ab2c1a05e40c3412
- 출처 데이터셋
- uspto-grants-1976_02
- 특허 번호
- US03939159
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