Triethylamine → 3-(4-Methoxyphenyl)cyclobutan-1-one

HRID 1578802노트

반응식

HRID 1578802 반응식
Cl[C:2]1[C:3](=[O:14])[CH2:4][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1.C(N(CC)CC)C>[Pd].CO>[CH3:13][O:12][C:9]1[CH:8]=[CH:7][C:6]([CH:5]2[CH2:4][C:3](=[O:14])[CH2:2]2)=[CH:11][CH:10]=1

참가 물질

5

반응물 2

HCID 8471TriethylamineHCID 214251912-Chloro-3-(p-methoxyphenyl)-2-cyclobuten-1-one

생성물 1

HCID 114466413-(4-Methoxyphenyl)cyclobutan-1-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-Chloro-3-(p-methoxyphenyl)-2-cyclobuten-1-one (17.4 g., 0.084 mole), triethylamine (11.7 ml., 0.084 mole), and 2.1 g. of 10% Pd/C in 300 ml. of 10% aqueous methanol is shaken under H2 (50 psi) until reduction is complete (30 min). The mixture is filtered and the filtrate evaporated. An ether solution of the residue is washed (water), dried (MgSO4), and evaporated to give 15.4 g. of an oil which is chromatographed on alumina using benzene.

후처리

  1. custom(30 min)
  2. filtrationThe mixture is filtered
  3. customthe filtrate evaporated
  4. washAn ether solution of the residue is washed (water)
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customto give 15.4 g
  8. customof an oil which is chromatographed on alumina

출처 및 근거

ORD 기록
ord-71cca5fb87c54723ba72c4103f608580
출처 데이터셋
uspto-grants-1976_02
특허 번호
US03939196

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