Ethanol → 1,3,5-Trimethyl-6-(2-(2-diethylaminoethoxy)phenyl)-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one

HRID 1578805노트

반응식

HRID 1578805 반응식
[CH3:1][N:2]1[C:6]([C:7](Cl)=[O:8])=[C:5]([N+:10]([O-])=O)[C:4]([CH3:13])=[N:3]1.[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[OH:21].[N+]([NH-])([O-])=O.N[NH-].N1C2C=NC=N[C:31]=2[C:30](=O)N=1.Cl.[CH2:39]([N:41]([CH2:44][CH2:45]Cl)[CH2:42][CH3:43])[CH3:40].C(O)C.[O-]CC.[Na+]>C(O)(=O)C>[CH3:1][N:2]1[C:6]2[C:7](=[O:8])[N:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[O:21][CH2:40][CH2:39][N:41]([CH2:44][CH3:45])[CH2:42][CH3:43])[C:30]([CH3:31])=[N:10][C:5]=2[C:4]([CH3:13])=[N:3]1

참가 물질

10

반응물 8

HCID 702EthanolHCID 58012-AminophenolHCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 168365Hydrazide (H3N21-)2회HCID 2723922Sodium ethoxideHCID 103756241,3-Dimethyl-4-nitro-5-pyrazolecarboxylic acid chlorideHCID 53630237PyrazolopyrimidinoneHCID 178514247HCID 178514247, 화합물

생성물 1

HCID 215585381,3,5-Trimethyl-6-(2-(2-diethylaminoethoxy)phenyl)-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

1,3-Dimethyl-4-nitro-5-pyrazolecarboxylic acid chloride is reacted with an equimolar quantity of o-aminophenol and the resulting nitroamide is catalytically reduced to the amino amide. Following the method of Example 2, the amino amide is cyclized with acetic acid in an autoclave and the resulting pyrazolopyrimidone is treated with an equimolar amount of diethylaminoethylchloride hydrochloride in absolute ethanol containing two equivalents of sodium ethoxide. 1,3,5-Trimethyl-6-(2-(2-diethylaminoethoxy)phenyl)-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one is obtained from the reaction mixture.

출처 및 근거

ORD 기록
ord-3911455a917d407eb578c6f2894bade6
출처 데이터셋
uspto-grants-1976_02
특허 번호
US03939161

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