1-Bromohexane → 1-Thiocyanohexane

HRID 1578999노트

반응식

HRID 1578999 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[S-:8][C:9]#[N:10].CN([S+](N(C)C)N(C)C)C>C(#N)C>[CH2:2]([S:8][C:9]#[N:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

4

반응물 2

HCID 81011-BromohexaneHCID 21557490Tris(dimethylamino)sulfonium thiocyanate

생성물 1

HCID 812571-Thiocyanohexane수율 85%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A 7.4-g (0.45 mole) sample of 1-bromohexane was added at ambient temperature to a stirred solution of 11.1 g (0.05 mole) of tris(dimethylamino)sulfonium thiocyanate in 25 ml acetonitrile, and the rate of the reaction was followed by gas-liquid partition chromatography (glc). The reaction was one-half completed after 3 hr, and was essentially completed after 20 hr. The reaction mixture was poured into water and extracted with ether. The ether extract was dried (MgSO4) and distilled to give 5.47 g (85%) of n-hexyl thiocyanate as a colorless liquid, bp 93°-94° (10 mm).

후처리

  1. custompartition chromatography (glc)
  2. waitwas essentially completed after 20 hr
  3. additionThe reaction mixture was poured into water
  4. extractionextracted with ether
  5. extractionThe ether extract
  6. dry with materialwas dried (MgSO4)
  7. distillationdistilled

출처 및 근거

ORD 기록
ord-1c104ef183624617a63209182e6ffb63
출처 데이터셋
uspto-grants-1976_02
특허 번호
US03940402

반응 노트

불러오는 중…