Morpholine → 4-Isopropylamino-2-morpholino-thieno[3,4-d]pyrimidine

HRID 1579424노트

반응식

HRID 1579424 반응식
Cl[C:2]1[N:3]=[C:4]([NH:11][CH:12]([CH3:14])[CH3:13])[C:5]2[C:6](=[CH:8][S:9][CH:10]=2)[N:7]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>O>[CH:12]([NH:11][C:4]1[C:5]2[C:6](=[CH:8][S:9][CH:10]=2)[N:7]=[C:2]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[N:3]=1)([CH3:14])[CH3:13]

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 215684292-Chloro-4-isopropylamino-thieno[3,4-d]pyrimidine

생성물 1

HCID 215684624-Isopropylamino-2-morpholino-thieno[3,4-d]pyrimidine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

6 g (0.26 moles) of 2-chloro-4-isopropylamino-thieno[3,4-d]pyrimidine and 25 mls. of morpholine are mixed and then heated under reflux for 4 hours. The mixture is cooled and poured into water with vigorous agitation; a brown solid appears, which is separated by filtration, washed with water and put to dry. The product is converted into the maleate, which is recrystallized from acetone. The free base is obtained again by treatment with alkali and is this way one obtains 3.4 g of pure product. M.P. 202°C. with decomposition.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 4 hours
  3. temperatureThe mixture is cooled
  4. customa brown solid appears, which is separated by filtration
  5. washwashed with water
  6. customto dry
  7. customis recrystallized from acetone
  8. customThe free base is obtained again by treatment with alkali and

출처 및 근거

ORD 기록
ord-685980e4ef7b491d939a9d7691cb4c6f
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03931204

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