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Water → aluminum 2-(5-oxo-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionate

HRID 1579454
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반응식

HRID 1579454 반응식
CC(C)[O-].[Al+3:5].CC(C)[O-].CC(C)[O-].[O:14]=[C:15]1[C:24]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[O:18][C:17]2[CH:25]=[CH:26][C:27]([CH:29]([CH3:33])[C:30]([OH:32])=[O:31])=[CH:28][C:16]1=2.O>C(O)(C)C>[O:14]=[C:15]1[C:24]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[O:18][C:17]2[CH:25]=[CH:26][C:27]([CH:29]([CH3:33])[C:30]([O-:32])=[O:31])=[CH:28][C:16]1=2.[Al+3:5].[O:14]=[C:15]1[C:24]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[O:18][C:17]2[CH:25]=[CH:26][C:27]([CH:29]([CH3:33])[C:30]([O-:32])=[O:31])=[CH:28][C:16]1=2.[O:14]=[C:15]1[C:24]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[O:18][C:17]2[CH:25]=[CH:26][C:27]([CH:29]([CH3:33])[C:30]([O-:32])=[O:31])=[CH:28][C:16]1=2
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 962WaterHCID 11143Aluminum isopropoxideHCID 122741862-(5-oxo-5H-chromeno[2,3-b]pyridin-7-yl)propanoic acid

생성물 1

HCID 21568501aluminum 2-(5-oxo-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionate

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

실험 절차

A solution of 2 g of aluminum isopropoxide in 30 ml of isopropyl alcohol is added dropwise to a solution of 2.7 g of 2-(5-oxo-5H-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid in 100 ml of isopropyl alcohol with stirring. The addition is accompanied by immediate formation of white crystals. The mixture is stirred under reflux for 1 hour, and 20 ml of water is added to the reaction mixture, and then the whole mixture is refluxed for an additional hour. After cooling, the crystals are filtered off, washed with isopropyl alcohol, and dried to give aluminum 2-(5-oxo-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionate as white crystals melting at above 250°C.

후처리

  1. additionThe addition
  2. stirringThe mixture is stirred
  3. temperatureunder reflux for 1 hour
  4. temperaturethe whole mixture is refluxed for an additional hour
  5. temperatureAfter cooling
  6. filtrationthe crystals are filtered off
  7. washwashed with isopropyl alcohol
  8. customdried

출처 및 근거

ORD 기록
ord-351e581c716946988940ed49687f6276
출처 데이터셋
uspto-grants-1976_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US03931205

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