1,3-Dibromopropane → 10-Phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol

HRID 1579527노트

반응식

HRID 1579527 반응식
[NH2:1][C:2]1[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([OH:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:19][CH2:20][CH2:21]Br>C(O)(C)C>[C:12]1([C:10]2([OH:11])[C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[N:3]3[CH2:19][CH2:20][CH2:21][N:1]=[C:2]23)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 80011,3-DibromopropaneHCID 215687052-amino-3-phenyl-3H-indol-3-ol

생성물 1

HCID 1507593810-Phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

2-Amino-3-phenyl-3H-indol-3-ol (2.24 g) was heated under reflux with isopropanol (20 ml) and 1,3-dibromopropane (2.0 g) for 20 hours. The reaction mixture was evaporated to 10 ml and diluted with a little ether. The title compound was obtained as its hydrobromide salt 0.73 g., m.p. 260°-262°C (decomp.) and could be recrystallized from methanol, ethanol or isopropanol with or without the addition of ethyl acetate or ether.

후처리

  1. customThe reaction mixture was evaporated to 10 ml
  2. additiondiluted with a little ether

출처 및 근거

ORD 기록
ord-4d5a026f279c4f2688f8270abe7bd5c8
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03931226

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